Cortical surface morphology in long-term cannabis users: A multi-site MRI study

Y Chye; C Suo; V Lorenzetti; A Batalla; J Cousijn; AE Goudriaan; R Martin-Santos; S Whittle; N Solowij; M Yücel

Journal article

Cortical surface morphology in long-term cannabis users: A multi-site MRI study

Y Chye, C Suo, V Lorenzetti, A Batalla, J Cousijn, AE Goudriaan, R Martin-Santos, S Whittle, N Solowij, M Yücel

European Neuropsychopharmacology | ELSEVIER | Published : 2019

DOI: 10.1016/j.euroneuro.2018.11.1110

Abstract

Cannabis exerts its psychoactive effect through cannabinoid receptors that are widely distributed across the cortical surface of the human brain. It is suggested that cannabis use may contribute to structural alterations across the cortical surface. In a large, multisite dataset of 120 controls and 141 cannabis users, we examined whether differences in key characteristics of the cortical surface – including cortical thickness, surface area, and gyrification index were related to cannabis use characteristics, including (i) cannabis use vs. non-use, (ii) cannabis dependence vs. non-dependence vs. non-use, and (iii) early adolescent vs. late adolescent onset of cannabis use vs. non-use. Our res..

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University of Melbourne Researchers

Sarah Whittle Author

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Grants

Awarded by Schizophrenia Research Fund

Funding Acknowledgements

Original data collection was supported by the Netherlands Organisation for Scientific Research, the Netherlands Organisation for Health Research and Development, ZonMw (AG, grant #31180002); an Amsterdam Brain Imaging Platform grant (JC); Plan Nacional sobre Drogas. Ministerio de Sanidad y Politica Social (Grant Plan Nacional sobre Drogas (PNSD). Ministerio de Sanidad y Politica Social of Spain: 2011/050 and DIUE de la Generalitat de Catalunya SGR: 2014/1114); the Clive and Vera Ramaciotti Foundation for Biomedical Research (NS); the Schizophrenia Research Institute with NSW Health (NS); and the National Health and Medical Research Council (NHMRC) of Australia (NS, Project Grant #459111).